Covid reinfections are not benign: ~39,000 people w/reinfections vs ~5.4 million controls indicates extensive and persistent risk with a “dose-response” (more risk with repeat reinfections) https://t.co/v8nZXBEuNd
by @zalaly @BCBowe @Biostayan @WUSTLmed @VAResearch pic.twitter.com/U4pPQZLEaB— Eric Topol (@EricTopol) June 21, 2022
Key findings include:
- “Compared to the non-infected control group, those who only had one infection had an increased risk of at least one sequela (HR 1.35 (1.4, 1.36); burden 84.13 (82.03, 86.24));”
- “the risk was higher in those who had two infections (HR 2.11 (2.07, 2.15); burden 234.58 (227.08, 241.92)),”
- risk was “highest in those with three or more infections (HR 3.00 (2.71, 3.31); burden 362.82 (326.37, 398.08)).”
- “In pairwise comparison of those with two infections vs first infection, those with two infections had an increased risk of at least one sequela (HR 1.57 (1.53, 1.60); burden 150.36 (142.95, 157.79));”
- “in pairwise comparison of those with three or more infections vs those with only two infections, those with three or more infections had a higher risk of at least one sequela (HR 1.42 (1.28, 1.57); burden 128.33 (91.88, 164.31)). “
Extremely important paper on: Outcomes of Covid Reinfection
Compared to those with first infection, reinfection led to increased risk at 6 months of: mortality by 2.38%, hospitalization 9.5% and post covid medical events 19.6%.
1/https://t.co/UZGraPtF29 pic.twitter.com/g65XlY39tn
— Yaneer Bar-Yam (@yaneerbaryam) June 20, 2022
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